The Japanese Plasmalogen Society
English

Purpose

We aim at achieving the following:

  • Joint research concerning plasmalogens
  • Contribution to treatment and prevention of psychosomatic disorders including Alzheimer’s disease, depression, Parkinson’s disease, behavioral disorders such as truancy, and metabolic syndrome by implementing the research on “Brain Fatigue” through the joint research
  • Academic activities intended to give back to the society

The Japanese Plasmalogen Society shall engage in the following operations to serve the above-mentioned purposes.

  1. Joint research and commissioned research matching the purpose
  2. Release of our research results at a study meeting or lecture meeting more than once a year
  3. Other activities necessary for achieving the purpose

Members

  • Yutaka OOMURA
    Representative Director
    Professor Emeritus, Kyushu University (Integrative Physiology)
  • Takehiko FUJINO
    Director (Chief Director of Clinical Research Division)
    Professor Emeritus, Kyushu University
    Director, BOOCS Medical Group
  • Shiro MAWATARI
    Director
    Director, Institute of Rheological Functions of Food
  • Yukio FUJIKI
    Director
    Professor, Medical Institute of Bioregulation, Kyushu University
  • Toshihiko KATAFUCHI
    Director
    Professor, Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University
  • Yoshio TSUBOI
    Director
    Professor, Department of Neurology, School of Medicine, Fukuoka University
  • Tatsuo YAMADA
    Director
    Former Professor, Department of Neurology, School of Medicine, Fukuoka University
  • Takashi ASADA
    Director
    Former Professor, Graduate School of Comprehensive Human Sciences Majors of Medical Sciences, University of Tsukuba
  • Junichi KIRA
    Director
    Professor, Department of Neurology and Neurological Institute, Graduate School of Medicine, Kyushu University
  • Shinji OUMA
    Auditor
    Assistant Professor, Department of Neurology, School of Medicine, Fukuoka University
  • Nobuyuki NAKAHARA
    Advisor
    Chief Director, The American Studies Foundation
    Former Member of the Policy Board, Bank of Japan
  • Suminori KONO
    Statistical Advisor
    Director, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition
  • Tatsuo OKAUCHI
    Councilor
    Associate Professor, Department of Materials Science, Faculty of Engineering, Kyushu Institute of Technology
  • Mitsuru KITAMURA
    Councilor
    Professor, Department of Materials Science, Faculty of Engineering, Kyushu Institute of Technology
  • Masanori Honsho
    Councilor
    Associate Professor, Medical Institute of Bioregulation, Kyushu University
  • Tsutomu HOSHUYAMA
    Councilor
    Lecturer, University of Occupational and Environmental Health

Contact Us

For any enquiries, please contact us via e-mail at info@pls.jp

Research Papers

  • Fujino T, Yamada T, Asada T, Tsuboi Y, Wakana C, Mawatari S, Kono S. Efficacy and blood plasmalogen changes by oral administration of plasmalogen in patients with mild Alzheimer’s disease and mild cognitive impairment: a multicenter, randomized, double-blind, placebo-controlled trial. EBioMedicine. 2017 Mar 17:199-205. doi: http://dx.doi.org/10.1016/j.ebiom.2017.02.012
  • Hossain MS, Abe Y, Fatma Ali, Mohammed Y, Honsho M, Fujiki Y, Katafuchi T. Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation. J. Neurosci. in press. 2017.
  • Honsho M, Abe Y, Fujiki Y. Plasmalogen synthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membrane. Sci. Report, in press 2017.
  • Hosoi KI, Miyata N, Mukai S, Furuki S, Okumoto K, Cheng EH, Fujiki Y. The VDAC2-BAK axis regulates peroxisomal membrane permeability. J Cell Biol. in press 2017.
  • Yagita Y, Shinohara K, Abe Y, Nakagawa K, Al-Owain M, Alkuraya FS, Fujiki Y. Deficiency of a Retinal Dystrophy Protein, Acyl-CoA Binding Domain-containing 5 (ACBD5), Impairs Peroxisomal β-Oxidation of Very-long-chain Fatty Acids. J Biol Chem. 2017 Jan 292(2):691-705.
  • Mawatari S, Hazeyama S, Fujino T. Measurement of ether phospholipids in human plasma with HPLC-ELSD and LC/ESI-MS after hydrolysis of plasma with phospholipase A1. Lipids. 2016 Aug 51(8):997-1006.
  • Hossain MS, Mineno K, Katafuchi T. Neuronal orphan G-protein coupled receptor proteins mediate plasmalogens-induced activation of ERK and Akt signaling. PLoS One. 2016 Mar 11(3):e0150846.
  • Fujiki Y. Peroxisome biogenesis and human peroxisome-deficiency disorders. Proc Jpn Acad Ser B Phys Biol Sci. 2016, 92(10):463-477.
  • Honsho M, Abe Y, Fujiki Y. Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis. J Biol Chem. 2015 Nov 290(48):28822-33.
  • Fujiki Y, Okumoto K, Mukai S, Honsho M, Tamura S. Peroxisome biogenesis in mammalian cells.
    Front Physiol. 2014 Aug 5:307.
  • Noguchi M, Honsho M, Abe Y, Toyama R, Niwa H, Sato Y, Ghaedi K, Rahmanifar A, Shafeghati Y, Fujiki Y. Mild reduction of plasmalogens causes rhizomelic chondrodysplasia punctata: functional characterization of a novel mutation. J Hum Genet. 2014 Jul 59(7):387-92.
  • Abe Y, Honsho M, Nakanishi H, Taguchi R, Fujiki Y. Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency. Biochim Biophys Acta. 2014 Apr 1841(4):610-9.
  • Hossain MS, Ifuku M, Take S, Kawamura J, Miake K, Katafuchi T. Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling. PLoS One. 2013 Dec 8(12):e83508.
  • Honsho M, Asaoku S, Fukumoto K, Fujiki Y. Topogenesis and homeostasis of fatty acyl-CoA reductase 1. J Biol Chem. 2013 Nov 288(48):34588-98.
  • Ifuku M, Katafuchi T, Mawatari S, Noda M, Miake K, Sugiyama M, Fujino T. Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice. J Neuroinflammation. 2012 Aug 9:197.
  • Katafuchi T, Ifuku M, Mawatari S, Noda M, Miake K, Sugiyama M, Fujino T. Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice. Ann N Y Acad Sci. 2012 Jul 1262:85-92.
  • Oma S, Mawatari S, Saito K, Wakana C, Tsuboi Y, Yamada T, Fujino T. Changes in phospholipid composition of erythrocyte membrane in Alzheimer’s disease. Dement Geriatr Cogn Dis Extra. 2012 Jan 2(1):298-303.
  • Yunoki K, Renaguli M, Kinoshita M, Matsuyama H, Mawatari S, Fujino T, Kodama Y, Sugiyama M, Ohnishi M. Dietary sphingolipids ameliorate disorders of lipid metabolism in Zucker fatty rats. J Agric Food Chem. 2010 Jun 58(11):7030-5.
  • Mawatari S, Yunoki K, Sugiyama M, Fujino T. Simultaneous preparation of purified plasmalogens and sphingomyelin in human erythrocytes with phospholipase A1 from Aspergillus orizae. Biosci Biotechnol Biochem. 2009 Dec 73(12):2621-5.
  • Mawatari S, Okuma Y, Fujino T. Separation of intact plasmalogens and all other phospholipids by a single run of high-performance liquid chromatography. Anal Biochem. 2007 Nov 370(1):54-9.

[YouTube] Plasmalogen can improve and prevent Dementia